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What is the Treatment for Repeated IVF Failure?

In vitro fertilization (IVF) is a widely used assisted reproductive technology (ART) that involves fertilizing an egg with sperm outside the body, typically in a laboratory. Despite its advancements, IVF can sometimes result in failure, especially in cases of repeated attempts. Repeated IVF failure refers to the inability to achieve a successful pregnancy after multiple IVF cycles.

Finding effective treatment options for couples experiencing repeated IVF failures is crucial. This is because repeated IVF failures can be emotionally and financially draining for couples. It can also indicate underlying issues that may need to be addressed to improve the chances of a successful conception and a healthy pregnancy. By understanding the causes of repeated IVF failure and exploring appropriate treatments, couples can increase their chances of achieving their dream of parenthood.

Common Treatments for Repeated IVF Failure

The treatment for repeated IVF failure often involves advanced assisted reproductive technologies that can significantly increase the chances of successful conception and a healthy pregnancy. So, what is the treatment for repeated IVF failure?

The simple direct answer is – “In cases of repeated IVF failure, intracytoplasmic sperm injection (ICSI), preimplantation genetic testing for aneuploidies (PGT-A), and endometrial scratch are advanced treatments that significantly increase the chances of successful conception and a healthy pregnancy.

Intracytoplasmic Sperm Injection (ICSI)

ICSI is an advanced ART technique that involves injecting a single sperm directly into an egg to facilitate fertilization. This procedure is particularly beneficial in cases where male factor infertility is a concern, such as low sperm count or poor sperm motility. By bypassing natural barriers to fertilization, ICSI can significantly increase the chances of successful conception, even in cases of repeated IVF failure.

Preimplantation Genetic Testing for Aneuploidies (PGT-A)

PGT-A is a procedure used to screen embryos for chromosomal abnormalities before implantation. This screening helps identify embryos with the correct number of chromosomes, increasing the chances of selecting a healthy embryo for transfer. By improving the selection process, PGT-A can enhance the chances of a successful pregnancy and reduce the risk of miscarriage in couples experiencing repeated IVF failure.

Endometrial Scratch

Endometrial scratching is a procedure in which the lining of the uterus (endometrium) is gently scratched or disturbed before embryo transfer during an IVF cycle. This procedure is believed to create a controlled injury to the endometrium, which can stimulate a healing response and promote a more receptive environment for embryo implantation.

In cases of repeated implantation failure, where embryos fail to implant in the uterus, endometrial scratch is thought to improve implantation outcomes by:

  • Promoting Endometrial Healing: The scratch stimulates the release of growth factors and cytokines, which may promote endometrial healing and improve its receptivity to embryos.
  • Enhancing Implantation Window: The procedure may also alter the timing of the implantation window, making the endometrium more receptive to embryo implantation.
  • Increasing Blood Flow: Endometrial scratch can increase blood flow to the uterus, which may enhance the delivery of nutrients and oxygen to the developing embryo, improving its chances of successful implantation.

Factors Contributing to Repeated IVF Failure

Here are two major reasons that contribute to repeated IVF failure, following below –

Chromosomal Abnormalities in Embryos

One of the common causes of IVF failure is chromosomal abnormalities in embryos. These abnormalities can occur spontaneously or due to issues with egg or sperm quality. As women age, the likelihood of chromosomal abnormalities in their eggs increases, which can lead to failed fertilization, failed implantation, or early pregnancy loss. This is why genetic testing of embryos (preimplantation genetic testing, or PGT-A) is often recommended, especially for couples experiencing repeated IVF failure.

Impact of Advanced Maternal Age

Advanced maternal age (typically considered to be over 35 years old) is associated with a decline in egg quality and quantity. As women age, the number of chromosomal abnormalities in their eggs increases, which can result in failed fertilization, failed implantation, or early pregnancy loss. This decline in egg quality can significantly impact the success rates of IVF, especially in cases of repeated IVF failure.

What Are the Success Rates After Failed IVF?

After experiencing failed IVF cycles, many couples wonder about their chances of success in subsequent attempts. The likelihood of successful conception in future IVF cycles can vary based on several factors, including the cause of previous failures, the age of the woman, and any changes made to the treatment protocol.

Despite initial setbacks, research shows that couples have good chances of achieving a successful pregnancy with additional IVF attempts. Cumulative live birth rates after multiple IVF cycles can range from 51% to 70%, indicating that persistence can pay off for many couples.

It’s important for couples to discuss their previous IVF experiences with their fertility specialist, who can provide personalized insights and recommendations for increasing the chances of success in future attempts.

Prevention Strategies for Repeated IVF Failure

“To prevent repeated IVF failure, quit smoking, limit alcohol, maintain a healthy weight, follow a balanced diet, and monitor the ovarian response closely during treatment.”

Lifestyle Factors Affecting IVF Outcomes

Several lifestyle factors can negatively impact the success of IVF treatment. These include:

  • Smoking: Smoking can reduce the success rate of IVF and increase the risk of miscarriage. It’s advisable for both partners to quit smoking before undergoing IVF treatment.
  • Excessive Alcohol Consumption: Heavy alcohol consumption can impair fertility and reduce the chances of successful IVF treatment. It’s recommended to limit alcohol intake or avoid it altogether during IVF treatment.
  • Obesity: Obesity is associated with reduced fertility and lower success rates of IVF. Maintaining a healthy weight through diet and exercise can improve IVF outcomes.
  • Poor Diet: A balanced diet rich in nutrients is important for fertility and IVF success. Consuming a variety of fruits, vegetables, whole grains, and lean proteins can improve overall health and fertility.

Importance of Ovarian Response to Stimulation Medications

During IVF treatment, women undergo ovarian stimulation to produce multiple eggs for retrieval. The response to stimulation medications can vary among women, with some experiencing inadequate or excessive ovarian response.

Inadequate ovarian response can result in fewer eggs retrieved, reducing the chances of success, while excessive response can lead to ovarian hyperstimulation syndrome (OHSS), a potentially serious complication. Monitoring ovarian response closely and adjusting medication doses as needed can help optimize IVF outcomes.


Understanding the causes and treatments for repeated IVF failure is crucial for couples seeking successful conception. Key points include the use of advanced techniques like ICSI and PGT-A, as well as lifestyle modifications to improve outcomes.

It’s important for couples to remain hopeful and explore the different treatment options available to them. Consulting with fertility specialists for personalized recommendations can greatly increase their chances of achieving a successful pregnancy. With perseverance and the right support, many couples can overcome the challenges of repeated IVF failure and realize their dream of parenthood.

Vardaan Medical Center offers personalised IVF treatments tailored to each individual’s needs, ensuring the highest chances of success. For those who are looking for  top-tier ivf centre in Jalandhar and IVF centre in Amritsar, Vardaan Medical Center is the trusted destination for realizing dreams of starting or expanding a family.

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